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Article

Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization

2 Nov 2017

Abstract excerpt

Norovirus is the leading cause of gastroenteritis worldwide. Despite recent developments in norovirus propagation in cell culture, these viruses are still challenging to grow routinely. Moreover, little is known on how norovirus infects the host cells, except that histo-blood group antigens (HBGAs) are important binding factors for infection and cell entry. Antibodies that bind at the HBGA pocket and block...

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PMID: 29095961
DOI: 10.1371/journal.ppat.1006636

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