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Article

A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity

16 Oct 2023

Abstract excerpt

Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus undergoes epochal evolution with periodic emergence of variants with new antigenic profiles and altered specificity for histo-blood group antigens (HBGA), the determinants of cell attachment...

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PMID: 37845211
DOI: 10.1038/s41467-023-42146-0

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