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Article

Activation of the hypoxia response in the aging cerebrovasculature protects males against cognitive impairment

2 Jul 2024

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder with a distinct sex bias. Age-related vascular alterations, a hallmark of AD onset and progression, are consistently associated with sexual dimorphism. Here, we conducted an integrative meta-analysis of 335,803 single-nucleus transcriptomes and 667 bulk transcriptomes from the vascular system in AD and normal aging to address the underlying sex-dependent...

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PMID: 38953594
DOI: 10.1111/acel.14264

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