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Article

A multi-bin rarefying method for evaluating alpha diversities in TCR sequencing data.

Bioinformatics (Oxford, England) - 1 Jul 2024

Li Mo, Hua Xing, Li Shuai, Wu Michael C, Zhao Ni

Abstract excerpt

MOTIVATION: T cell receptors (TCRs) constitute a major component of our adaptive immune system, governing the recognition and response to internal and external antigens. Studying the TCR diversity via sequencing technology is critical for a deeper understanding of immune dynamics. However, library sizes differ substantially across samples, hindering the accurate estimation/comparisons of alpha diversities. To...

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Identifiers

PMID: 38950175
DOI: 10.1093/bioinformatics/btae431
PMCID: PMC11246167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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