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Article

Computational estimation of clonal diversity in autoimmunity.

Immunology and cell biology - 1 Sept 2024

Tuong Zewen Kelvin, van der Merwe Rohan, Canete Pablo F, Roco Jonathan A

Abstract excerpt

Diversity is the cornerstone of the adaptive immune system, crucial for its effectiveness against constantly evolving pathogens that pose threats to higher vertebrates. Accurately measuring and interpreting this diversity presents challenges for immunologists, as changes in diversity and clonotype composition can tip the balance between protective immunity and autoimmunity. In this review, we present the current...

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PMID: 39010261
DOI: 10.1111/imcb.12801

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