Article
Shared vulnerability and sex-dependent polygenic burden in psychotic disorders.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2024
Mitjans Marina, Papiol Sergi, Fatjó-Vilas Mar, González-Peñas Javier, Acosta-Díez Miriam, Zafrilla-López Marina, Costas Javier, Arango Celso, Vilella Elisabet, Martorell Lourdes, Moltó M Dolores, Bobes Julio, Crespo-Facorro Benedicto, González-Pinto Ana, Fañanás Lourdes, Rosa Araceli, Arias Bárbara
Abstract excerpt
Evidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sex-dependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372...
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