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Article

Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder.

JAMA psychiatry - 1 Dec 2024

Song Jie, Pasman Joëlle A, Johansson Viktoria, Kuja-Halkola Ralf, Harder Arvid, Karlsson Robert, Lu Yi, Kowalec Kaarina, Pedersen Nancy L, Cannon Tyrone D, Hultman Christina M, Sullivan Patrick F

Abstract excerpt

Importance: Schizophrenia and bipolar disorder are highly heritable psychiatric disorders with strong genetic and phenotypic overlap. Twin and molecular methods can be leveraged to predict the shared genetic liability to these disorders. Objective: To investigate whether twin concordance for psychosis depends on the level of polygenic risk score (PRS) for psychosis and zygosity and compare PRS from cases and...

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Identifiers

PMID: 39196586
DOI: 10.1001/jamapsychiatry.2024.2406
PMCID: PMC11359115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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