Polygenic risk for schizophrenia predicting Big Five personality traits in individuals without non-affective psychosis.

doi:10.1016/j.schres.2025.05.017

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Article

Polygenic risk for schizophrenia predicting Big Five personality traits in individuals without non-affective psychosis.

Schizophrenia research - 1 Jul 2025

Lavonius Veikka, Keltikangas-Järvinen Liisa, Lyytikäinen Leo-Pekka, Hamal Mishra Binisha, Sormunen Elina, Kähönen Mika, Raitakari Olli, Hietala Jarmo, Lehtimäki Terho, Saarinen Aino

Abstract excerpt

BACKGROUND: A high genetic risk for schizophrenia, in complex interplay with environmental factors, has been suggested to explain population-level variation in personality traits among individuals who do not develop schizophrenia-spectrum disorders. We investigated, first, whether polygenic risk for schizophrenia (PRSscz) predicts Big Five personality traits in individuals, who have not developed non-affective...

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Topics

Humans
Male
Female
Schizophrenia
Adult
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Young Adult

Personality

Finland

Genetic Predisposition to Disease

Psychotic Disorders

Schizophrenic Psychology

Prospective Studies

Adolescent

Source

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Identifiers

PMID: 40411924
DOI: 10.1016/j.schres.2025.05.017

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