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Article

Polygenic risk score for coronary artery disease predicts atherosclerotic cardiovascular disease in familial hypercholesterolemia.

Journal of clinical lipidology - 1 Jan 2025

Paquette Martine, Trinder Mark, Ruel Isabelle, Guay Simon-Pierre, Hegele Robert A, Genest Jacques, Brunham Liam R, Baass Alexis

Abstract excerpt

BACKGROUND: Patients with familial hypercholesterolemia (FH) are at increased risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is heterogeneous, and the contribution of several clinical risk factors has been well demonstrated in this population. The proportion of the risk conferred by the accumulation of common small effect variants in coronary artery disease (CAD) susceptibility genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40000284
DOI: 10.1016/j.jacl.2025.01.004

Genes

FH
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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