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Article

Influence of Polygenic Background on the Clinical Presentation of Familial Hypercholesterolemia.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2024

Trinder Mark, Cermakova Lubomira, Ruel Isabelle, Baass Alexis, Paquette Martine, Wang Jian, Kennedy Brooke A, Hegele Robert A, Genest Jacques, Brunham Liam R

Abstract excerpt

BACKGROUND: Heterozygous familial hypercholesterolemia (FH) is among the most common genetic conditions worldwide that affects ≈ 1 in 300 individuals. FH is characterized by increased levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of coronary artery disease (CAD), but there is a wide spectrum of severity within the FH population. This variability in expression is incompletely explained...

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Identifiers

PMID: 38779854
DOI: 10.1161/ATVBAHA.123.320287
PMCID: PMC11208056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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