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Article

Meta-analysis Driven Strain Design for Mitigating Oxidative Stresses Important in Biomanufacturing.

ACS synthetic biology - 19 Jul 2024

Phaneuf P V, Kim S H, Rychel K, Rode C, Beulig F, Palsson B O, Yang L

Abstract excerpt

As the availability of data sets increases, meta-analysis leveraging aggregated and interoperable data types is proving valuable. This study leveraged a meta-analysis workflow to identify mutations that could improve robustness to reactive oxygen species (ROS) stresses using an industrially important melatonin production strain as an example. ROS stresses often occur during cultivation and negatively affect...

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Identifiers

PMID: 38934464
DOI: 10.1021/acssynbio.3c00572
PMCID: PMC11264330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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