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Article

Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium.

Applied and environmental microbiology - 1 Jan 2015

LaCroix Ryan A, Sandberg Troy E, O'Brien Edward J, Utrilla Jose, Ebrahim Ali, Guzman Gabriela I, Szubin Richard, Palsson Bernhard O, Feist Adam M

Abstract excerpt

Adaptive laboratory evolution (ALE) has emerged as an effective tool for scientific discovery and addressing biotechnological needs. Much of ALE's utility is derived from reproducibly obtained fitness increases. Identifying causal genetic changes and their combinatorial effects is challenging and time-consuming. Understanding how these genetic changes enable increased fitness can be difficult. A series of...

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PMID: 25304508
DOI: 10.1128/AEM.02246-14
PMCID: PMC4272732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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