Article
Adaptive laboratory evolution for growth coupled microbial production.
World journal of microbiology & biotechnology - 21 Oct 2020
Godara Avinash, Kao Katy C
Abstract excerpt
Adaptive laboratory evolution (ALE) is a powerful tool to select for strains with growth-coupled phenotypes. When coupled with next-generation sequencing and omic technologies, genotype-to-phenotype relationships and the molecular mechanisms underlying desired complex phenotypes can now be uncovered using ALE. However, in order for ALE to be effective in generating strains with increased productivity, the...
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