Article
Experimental Evolution Reveals Unifying Systems-Level Adaptations but Diversity in Driving Genotypes.
mSystems - 20 Dec 2022
Kavvas Erol S, Long Christopher P, Sastry Anand, Poudel Saugat, Antoniewicz Maciek R, Ding Yang, Mohamed Elsayed T, Szubin Richard, Monk Jonathan M, Feist Adam M, Palsson Bernhard O
Abstract excerpt
Genotype-fitness maps of evolution have been well characterized for biological components, such as RNA and proteins, but remain less clear for systems-level properties, such as those of metabolic and transcriptional regulatory networks. Here, we take multi-omics measurements of 6 different E. coli strains throughout adaptive laboratory evolution (ALE) to maximal growth fitness. The results show the following: (i)...
Topics
- Escherichia coli
- NADP
- Adaptation, Physiological
- Genotype
- Mutation