Article
Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2008
Klein-Marcuschamer Daniel, Stephanopoulos Gregory
Abstract excerpt
Industrial strains have been traditionally improved by rational approaches and combinatorial methods involving mutagenesis and selection. Recently, other methods have emerged, such as the use of artificial transcription factors and engineering of the native ones. As methods for generating genetic diversity continue to proliferate, the need for quantifying phenotypic diversity and, hence, assessing the potential...
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