Article
Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity.
BMC genomics - 25 Jul 2020
Phaneuf Patrick V, Yurkovich James T, Heckmann David, Wu Muyao, Sandberg Troy E, King Zachary A, Tan Justin, Palsson Bernhard O, Feist Adam M
Abstract excerpt
BACKGROUND: Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover mutations that confer phenotypic functions of interest. However, the task of finding and understanding all beneficial mutations of an ALE experiment remains an open challenge for the field. To provide for better results than traditional methods of ALE mutation analysis, this work applied enrichment methods to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.