Escherichia coli Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data.

doi:10.1021/acssynbio.1c00337

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Article

Escherichia coli Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data.

ACS synthetic biology - 17 Dec 2021

Phaneuf Patrick V, Zielinski Daniel C, Yurkovich James T, Johnsen Josefin, Szubin Richard, Yang Lei, Kim Se Hyeuk, Schulz Sebastian, Wu Muyao, Dalldorf Christopher, Ozdemir Emre, Lennen Rebecca M, Palsson Bernhard O, Feist Adam M

Abstract excerpt

Microbes are being engineered for an increasingly large and diverse set of applications. However, the designing of microbial genomes remains challenging due to the general complexity of biological systems. Adaptive Laboratory Evolution (ALE) leverages nature's problem-solving processes to generate optimized genotypes currently inaccessible to rational methods. The large amount of public ALE data now represents a...

Topics

Escherichia coli
Escherichia coli K12
Escherichia coli Proteins
Laboratories
Mutation

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Identifiers

PMID: 34762392
DOI: 10.1021/acssynbio.1c00337
PMCID: PMC8870144

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