Article
Advanced strategies and tools to facilitate and streamline microbial adaptive laboratory evolution.
Trends in biotechnology - 1 Jan 2022
Wu Yinan, Jameel Aysha, Xing Xin-Hui, Zhang Chong
Abstract excerpt
Adaptive laboratory evolution (ALE) has served as a historic microbial engineering method that mimics natural selection to obtain desired microbes. The past decade has witnessed improvements in all aspects of ALE workflow, in terms of growth coupling, genotypic diversification, phenotypic selection, and genotype-phenotype mapping. The developing growth-coupling strategies facilitate ALE to a wider range of...
Topics
- Genetic Engineering
- Genotype
- Mutagenesis
- Phenotype