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Article

Diverse genetic error modes constrain large-scale bio-based production.

Nature communications - 20 Feb 2018

Rugbjerg Peter, Myling-Petersen Nils, Porse Andreas, Sarup-Lytzen Kira, Sommer Morten O A

Abstract excerpt

A transition toward sustainable bio-based chemical production is important for green growth. However, productivity and yield frequently decrease as large-scale microbial fermentation progresses, commonly ascribed to phenotypic variation. Yet, given the high metabolic burden and toxicities, evolutionary processes may also constrain bio-based production. We experimentally simulate large-scale fermentation with...

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Identifiers

PMID: 29463788
DOI: 10.1038/s41467-018-03232-w
PMCID: PMC5820350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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