Article
OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.
Molecular biology and evolution - 1 Mar 2020
Anand Amitesh, Chen Ke, Catoiu Edward, Sastry Anand V, Olson Connor A, Sandberg Troy E, Seif Yara, Xu Sibei, Szubin Richard, Yang Laurence, Feist Adam M, Palsson Bernhard O
Abstract excerpt
Oxidative stress is concomitant with aerobic metabolism. Thus, bacterial genomes encode elaborate mechanisms to achieve redox homeostasis. Here we report that the peroxide-sensing transcription factor, oxyR, is a common mutational target using bacterial species belonging to two genera, Escherichia coli and Vibrio natriegens, in separate growth conditions implemented during laboratory evolution. The mutations...
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