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Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals.

Metabolic engineering - 1 Mar 2023

Lennen Rebecca M, Lim Hyun Gyu, Jensen Kristian, Mohammed Elsayed T, Phaneuf Patrick V, Noh Myung Hyun, Malla Sailesh, Börner Rosa A, Chekina Ksenia, Özdemir Emre, Bonde Ida, Koza Anna, Maury Jérôme, Pedersen Lasse E, Schöning Lars Y, Sonnenschein Nikolaus, Palsson Bernhard O, Nielsen Alex T, Sommer Morten O A, Herrgård Markus J, Feist Adam M

Abstract excerpt

Although strain tolerance to high product concentrations is a barrier to the economically viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often unknown. To reveal tolerance mechanisms, an automated platform was utilized to evolve Escherichia coli to grow optimally in the presence of 11 industrial chemicals (1,2-propanediol, 2,3-butanediol, glutarate, adipate, putrescine,...

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PMID: 36738854
DOI: 10.1016/j.ymben.2023.01.012

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