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Article

Connection Failure: Differences in White Matter Microstructure Are Associated with 5-HTTLPR but Not with Risk Seeking for Losses.

International journal of molecular sciences - 18 Jun 2024

Neukam Philipp T, Müller Dirk K, Deza-Lougovski Yacila I, Pooseh Shakoor, Witt Stephanie H, Rietschel Marcella, Smolka Michael N

Abstract excerpt

S/S carriers of 5-HTTLPR have been found to be more risk seeking for losses compared to L/L carriers. This finding may be the result of reduced top-down control from the frontal cortex due to altered signal pathways involving the amygdala and ventral striatum. The serotonergic system is known to be involved in neurodevelopment and neuroplasticity. Therefore, the aim of this study was to investigate whether...

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Identifiers

PMID: 38928372
DOI: 10.3390/ijms25126666
PMCID: PMC11203796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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