Article

Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior – a TPH2 imaging genetics approach

2019-06-27

Abstract excerpt

<h4>Background</h4> Early life stress has been associated with emotional dysregulations and altered architecture of limbic-prefrontal brain systems engaged in emotional processing. Serotonin regulates both, developmental and experience-dependent neuroplasticity in these circuits. Central serotonergic biosynthesis rates are regulated by Tryptophan hydroxylase 2 ( TPH2 ), and transgenic animal models suggest that...

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Literature Corpus work: 72f6efee-718a-5089-b0ef-5c84d3cc4138
DOI: 10.1101/685099

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