Altered white matter architecture in BDNF met carriers.

doi:10.1371/journal.pone.0069290

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Article

Altered white matter architecture in BDNF met carriers.

PloS one - 1 Jan 2013

Ziegler Erik, Foret Ariane, Mascetti Laura, Muto Vincenzo, Le Bourdiec-Shaffii Anahita, Stender Johan, Balteau Evelyne, Dideberg Vinciane, Bours Vincent, Maquet Pierre, Phillips Christophe

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) modulates the pruning of synaptically silent axonal arbors. The Met allele of the BDNF gene is associated with a reduction in the neurotrophin's activity-dependent release. We used diffusion-weighted imaging to construct structural brain networks for 36 healthy subjects with known BDNF genotypes. Through permutation testing we discovered clear differences in connection...

Topics

Adolescent
Adult
Algorithms
Alleles
Brain
Brain Mapping
Brain-Derived Neurotrophic Factor
Corpus Callosum
Female
Gene Frequency
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Internal Capsule

Linkage Disequilibrium

Magnetic Resonance Imaging

Male

Methionine

Models, Neurological

Source

Open in PubMed Open full text

Identifiers

PMID: 23935975
DOI: 10.1371/journal.pone.0069290
PMCID: PMC3729843

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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