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Article

Cortico-limbic functional connectivity mediates the effect of early life stress on suicidality in bipolar depressed 5-HTTLPR*s carriers.

Journal of affective disorders - 15 Feb 2020

Vai Benedetta, Serretti Alessandro, Poletti Sara, Mascia Mattia, Lorenzi Cristina, Colombo Cristina, Benedetti Francesco

Abstract excerpt

BACKGROUND: In bipolar disorder (BD) the risk of suicide in adult life can be influenced by the interaction of adverse childhood experiences with the serotonin transporter polymorphism (5-HTTLPR). The cortico-limbic connectivity is a candidate endophenotype for the disorder, also related to suicidality and affected by the 5-HT system. METHODS: In 64 (*s carriers = 41; l/l = 23) depressed BD patients, we explored...

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Source

Identifiers

PMID: 31969273
DOI: 10.1016/j.jad.2019.11.142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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