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Article

Human CtIP: A ‘double agent’ in DNA repair and tumorigenesis

17 Sept 2020

Abstract excerpt

Human CtIP was originally identified as an interactor of the retinoblastoma protein and BRCA1, two bona fide tumour suppressors frequently mutated in cancer. CtIP is renowned for its role in the resection of DNA double-strand breaks (DSBs) during homologous recombination, a largely error-free DNA repair pathway crucial in maintaining genome integrity. However, CtIP-dependent DNA end resection is equally...

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PMID: 32950401
DOI: 10.1016/j.semcdb.2020.09.001

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