Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.

doi:10.1007/s00401-024-02755-5

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Article

Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.

Acta neuropathologica - 25 Jun 2024

Qu Wenhui, Lam Matti, McInvale Julie J, Mares Jason A, Kwon Sam, Humala Nelson, Mahajan Aayushi, Nguyen Trang, Jakubiak Kelly A, Mun Jeong-Yeon, Tedesco Thomas G, Al-Dalahmah Osama, Hussaini Syed A, Sproul Andrew A, Siegelin Markus D, De Jager Philip L, Canoll Peter, Menon Vilas, Hargus Gunnar

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia, and disease mechanisms are still not fully understood. Here, we explored pathological changes in human induced pluripotent stem cell (iPSC)-derived neurons carrying the familial AD APPV717I mutation after cell injection into the mouse forebrain. APPV717I mutant iPSCs and isogenic controls were differentiated into neurons revealing enhanced Aβ42...

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PMID: 38918213
DOI: 10.1007/s00401-024-02755-5
PMCID: PMC11199265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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