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Article

CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis.

Antioxidants & redox signaling - 1 Jan 2026

Zhou Han, Wang Chao, Wang Wentao, Guo Pin, Xu Yifan, Cui Zhenwen, Li Xiaolu, Li Shifang, Feng Yugong, Yu Tao

Abstract excerpt

AIMS: Intracranial aneurysm (IA) is a critical cerebrovascular disorder strongly linked to phenotypic switching and apoptosis of vascular smooth muscle cells (VSMCs). This study aimed to investigate the role of circGNAQ in IA development and elucidate its underlying molecular mechanisms. RESULTS: Reverse transcription-quantitative polymerase chain reaction and fluorescence in situ hybridization revealed...

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Apoptosis
Cells, Cultured
Disease Models, Animal
Intracranial Aneurysm
Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

Serine-Arginine Splicing Factors

Source

Identifiers

PMID: 40986450
DOI: 10.1177/15230864251380271

Genes

SRSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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