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Article

Semaphorin 7A aggravates abdominal aortic aneurysm through PDK1/SGK3/YTHDC1 axis-mediated phenotypic switching of vascular smooth muscle cells.

Cardiovascular research - 26 Mar 2026

Li Fengchan, Zhu Zhen, Tang Fan, Du Yun, Lyu Jiaxin, Wu Lili, Ni Haofu, Wang Ying, Ren Lijie, Lu Qiongyu, Liu Huihui, Hong Lei, Wang Hongjie, Tang Chaojun, Zhu Li

Abstract excerpt

AIMS: Semaphorin 7A (SEMA7A), a membrane-anchored glycoprotein involved in immune and vascular signalling, has been implicated in cardiovascular diseases. However, its role in the development of abdominal aortic aneurysm (AAA) has not been defined. In this study, we investigated the role of SEMA7A in AAA progression and the underlying mechanisms. METHODS AND RESULTS: A meta-analysis of genome-wide association...

Read the complete abstract on PubMed

Topics

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Share to 3-Phosphoinositide-Dependent Protein Kinases
Share to Aorta, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Abdominal

Share to GPI-Linked Proteins

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 41553434
DOI: 10.1093/cvr/cvag009

Genes

SEMA7A
PDK1
SGK3
YTHDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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