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Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging.

Nucleic acids research - 12 Aug 2024

Rieckher Matthias, Gallrein Christian, Alquezar-Artieda Natividad, Bourached-Silva Nour, Vaddavalli Pavana Lakshmi, Mares Devin, Backhaus Maria, Blindauer Timon, Greger Ksenia, Wiesner Eva, Pontel Lucas B, Schumacher Björn

Abstract excerpt

Formaldehyde (FA) is a recognized environmental and metabolic toxin implicated in cancer development and aging. Inherited mutations in the FA-detoxifying enzymes ADH5 and ALDH2 genes lead to FA overload in the severe multisystem AMeD syndrome. FA accumulation causes genome damage including DNA-protein-, inter- and intra-strand crosslinks and oxidative lesions. However, the influence of distinct DNA repair systems...

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Source

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Identifiers

PMID: 38894680
DOI: 10.1093/nar/gkae519
PMCID: PMC11317141

Genes

ADH5
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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