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Article

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.

Genome research - 1 Oct 2014

Meier Bettina, Cooke Susanna L, Weiss Joerg, Bailly Aymeric P, Alexandrov Ludmil B, Marshall John, Raine Keiran, Maddison Mark, Anderson Elizabeth, Stratton Michael R, Gartner Anton, Campbell Peter J

Abstract excerpt

Mutation is associated with developmental and hereditary disorders, aging, and cancer. While we understand some mutational processes operative in human disease, most remain mysterious. We used Caenorhabditis elegans whole-genome sequencing to model mutational signatures, analyzing 183 worm populations across 17 DNA repair-deficient backgrounds propagated for 20 generations or exposed to carcinogens. The baseline...

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PMID: 25030888
DOI: 10.1101/gr.175547.114
PMCID: PMC4199376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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