Article

Neuronal DNA repair mediates systemic mitochondrial maintenance through acetylcholine signaling

2026-02-12

Abstract excerpt

DNA repair defects such as Nucleotide Excision Repair (NER) mutations can lead to progeroid syndromes characterized by growth retardation and accelerated aging with distinct tissue type specific pathologies. DNA damage induced dysfunction of specific cell types can impair the organism’s overall function. It is unknown whether, in reverse, DNA repair in specific tissues can have non-cell-autonomous consequences on...

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Literature Corpus work: e7dc3e4f-cc5e-54bf-a4f6-1d40d38f39aa
DOI: 10.64898/2026.02.11.705232

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