Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans.

Mechanisms of ageing and development - 1 Dec 2021

Marchal Lucile, Hamsanathan Shruthi, Karthikappallil Roshan, Han Suhao, Shinglot Himaly, Gurkar Aditi U

Abstract excerpt

Although the link between DNA damage and aging is well accepted, the role of different DNA repair proteins on functional/physiological aging is not well-defined. Here, using Caenorhabditis elegans, we systematically examined the effect of three DNA repair genes involved in key genome stability pathways. We assayed multiple health proxies including molecular, functional and resilience measures to define...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Helicases

Share to Genomic Instability

Share to Longevity

Share to Oxidative Stress

Share to Recombinational DNA Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 34562508
DOI: 10.1016/j.mad.2021.111573
PMCID: PMC8627479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans.PMID 34562508Read ↗

Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.Semantic proximity Read ↗

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.Semantic proximity Read ↗

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced agingSemantic proximity Read ↗

DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.Semantic proximity Read ↗

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans.Semantic proximity Read ↗

Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging.Semantic proximity Read ↗

A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways.Semantic proximity Read ↗

A Genetic Analysis of the Caenorhabditis elegans Detoxification Response.Semantic proximity Read ↗

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.Semantic proximity Read ↗

The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.Semantic proximity Read ↗

Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised <i>C. elegans</i>Semantic proximity Read ↗

Protecting the Aging Genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.