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Article

Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.

Nucleic acids research - 1 Mar 2008

Hyun Moonjung, Lee Jihyun, Lee Kyungjin, May Alfred, Bohr Vilhelm A, Ahn Byungchan

Abstract excerpt

DNA repair is an important mechanism by which cells maintain genomic integrity. Decline in DNA repair capacity or defects in repair factors are thought to contribute to premature aging in mammals. The nematode Caenorhabditis elegans is a good model for studying longevity and DNA repair because of key advances in understanding the genetics of aging in this organism. Long-lived C. elegans mutants have been...

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Identifiers

PMID: 18203746
DOI: 10.1093/nar/gkm1161
PMCID: PMC2275101

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