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Article

Hierarchical joint analysis of marginal summary statistics-Part II: High-dimensional instrumental analysis of omics data.

Genetic epidemiology - 1 Oct 2024

Jiang Lai, Shen Jiayi, Darst Burcu F, Haiman Christopher A, Mancuso Nicholas, Conti David V

Abstract excerpt

Instrumental variable (IV) analysis has been widely applied in epidemiology to infer causal relationships using observational data. Genetic variants can also be viewed as valid IVs in Mendelian randomization and transcriptome-wide association studies. However, most multivariate IV approaches cannot scale to high-throughput experimental data. Here, we leverage the flexibility of our previous work, a hierarchical...

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PMID: 38887957
DOI: 10.1002/gepi.22577
PMCID: PMC12333930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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