Article
JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects.
Genetic epidemiology - 1 Apr 2016
Newcombe Paul J, Conti David V, Richardson Sylvia
Abstract excerpt
Recently, large scale genome-wide association study (GWAS) meta-analyses have boosted the number of known signals for some traits into the tens and hundreds. Typically, however, variants are only analysed one-at-a-time. This complicates the ability of fine-mapping to identify a small set of SNPs for further functional follow-up. We describe a new and scalable algorithm, joint analysis of marginal summary...
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