Article
Hierarchical joint analysis of marginal summary statistics-Part I: Multipopulation fine mapping and credible set construction.
Genetic epidemiology - 1 Sept 2024
Shen Jiayi, Jiang Lai, Wang Kan, Wang Anqi, Chen Fei, Newcombe Paul J, Haiman Christopher A, Conti David V
Abstract excerpt
Recent advancement in genome-wide association studies (GWAS) comes from not only increasingly larger sample sizes but also the shift in focus towards underrepresented populations. Multipopulation GWAS increase power to detect novel risk variants and improve fine-mapping resolution by leveraging evidence and differences in linkage disequilibrium (LD) from diverse populations. Here, we expand upon our previous...
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