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Article

Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Nov 2024

Rasing Ingeborg, Vlegels Naomi, Schipper Manon R, Voigt Sabine, Koemans Emma A, Kaushik Kanishk, van Dort Rosemarie, van Harten Thijs W, De Luca Alberto, van Etten Ellis S, van Zwet Erik W, van Buchem Mark A, Middelkoop Huub Am, Biessels Geert Jan, Terwindt Gisela M, van Osch Matthias Jp, van Walderveen Marianne Aa, Wermer Marieke Jh

Abstract excerpt

Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI...

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Identifiers

PMID: 38886875
DOI: 10.1177/0271678X241261771
PMCID: PMC11542140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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