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Article

Cerebral Amyloid Angiopathy Burden and Cerebral Microbleeds: Pathological Evidence for Distinct Phenotypes.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Graff-Radford Jonathan, Lesnick Timothy G, Mielke Michelle M, Constantopoulos Eleni, Rabinstein Alejandro A, Przybelski Scott A, Vemuri Prashanthi, Botha Hugo, Jones David T, Ramanan Vijay K, Petersen Ronald C, Knopman David S, Boeve Bradley F, Murray Melissa E, Dickson Dennis W, Jack Clifford R, Kantarci Kejal, Reichard R Ross

Abstract excerpt

BACKGROUND: The relationship between cerebral microbleeds (CMBs) on hemosiderin-sensitive MRI sequences and cerebral amyloid angiopathy (CAA) remains unclear in population-based participants or in individuals with dementia. OBJECTIVE: To determine whether CMBs on antemortem MRI correlate with CAA. METHODS: We reviewed 54 consecutive participants with antemortem T2*GRE-MRI sequences and subsequent autopsy. CMBs...

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Identifiers

PMID: 33720897
DOI: 10.3233/JAD-201536
PMCID: PMC8113155

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