Article

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions

2025-06-11

Abstract excerpt

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology. Current imaging methods have lacked the specificity to disentangle biological processes underlying WMHs in vivo . Here, we used voxel-level normative modeling and seven microstructural MRI markers with comple...

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Literature Corpus work: a8373caf-bd20-58ec-8be5-97b408d9e92a
DOI: 10.1101/2025.06.10.25329342

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