The association of Apolipoprotein E ε4 with symptomatic intracerebral hemorrhage, MRI markers and cognition in Dutch-type hereditary cerebral amyloid angiopathy.

doi:10.1016/j.jstrokecerebrovasdis.2026.108593

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Article

The association of Apolipoprotein E ε4 with symptomatic intracerebral hemorrhage, MRI markers and cognition in Dutch-type hereditary cerebral amyloid angiopathy.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Apr 2026

van der Plas Maaike C, van Dort Rosemarie, Rasing Ingeborg, Long Yongxi, van Zwet Erik W, van Osch Matthias J P, Sohrabi Hamid R, Taddei Kevin, Gardener Samantha L, Martins Ralph N, Greenberg Steven M, Terwindt Gisela M, van Walderveen Marianne A A, Wermer Marieke J H

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) genotype influences the presence, course and severity of sporadic cerebral amyloid angiopathy (sCAA). We investigated the effect of the APOE ε4-allele on clinical and neuroradiological outcomes in mutation-carriers with Dutch-type hereditary (D-)CAA. METHODS: Participants with D-CAA from a prospective cohort study, with data collected on history of symptomatic intracerebral...

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PMID: 41707816
DOI: 10.1016/j.jstrokecerebrovasdis.2026.108593

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