Article

Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease

2025-02-14

Abstract excerpt

<title>Abstract</title> <p>Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD), a leading cause of stroke and dementia with no mechanism-based treatment. We conducted a genome-wide association study of PSMD in 58,403 participants from 24 population-based cohorts (89% European, 10% East-Asia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 182297a1-dd7e-5a17-a02e-fb61478008b8
DOI: 10.21203/rs.3.rs-5926137/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel diseaseDOI 10.21203/rs.3.rs-5926137/v1Read

Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease.Semantic proximity Read

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel diseaseSemantic proximity Read

Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel diseaseSemantic proximity Read

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.Semantic proximity Read

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel diseaseSemantic proximity Read

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel diseaseSemantic proximity Read

Genome-wide association study of enlarged perivascular spaces: results from two large population-based cohortsSemantic proximity Read

A foundation model for mapping the phenomic and genetic landscape of cerebral small vessel disease biomarkersSemantic proximity Read

Race- and sex-specific disease trajectory in individuals with rare variants in seven cerebrovascular small vessel disease genes: a genotype-first population studySemantic proximity Read

Plasma Proteomics and Sensitive Imaging Biomarkers of Vascular Brain InjurySemantic proximity Read

cSVI-subtype: a GWAS-anchored, vascular-centered framework for molecular subtype barcode discovery in cerebral small vessel diseaseSemantic proximity Read