Article
Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.
International journal of molecular sciences - 13 Mar 2021
Chatterjee Pratishtha, Tegg Michelle, Pedrini Steve, Fagan Anne M, Xiong Chengjie, Singh Abhay K, Taddei Kevin, Gardener Samantha, Masters Colin L, Schofield Peter R, Multhaup Gerhard, Benzinger Tammie L S, Morris John C, Bateman Randall J, Greenberg Steven M, van Buchem Mark A, Stoops Erik, Vanderstichele Hugo, Teunissen Charlotte E, Hankey Graeme J, Wermer Marieke J H, Sohrabi Hamid R, Martins Ralph N, The Dominantly Inherited Alzheimer Network
Abstract excerpt
Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre-symptomatic Dutch-type hereditary CAA (D-CAA) mutation-carriers (MC) and non-carriers (NC) using two Aβ measurement...
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