Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Jul 2024

Huang 黄玉莹 Yuying, Shao 邵建英 Jian-Ying, Chen 陈红 Hong, Zhou 周京京 Jing-Jing, Chen 陈少瑞 Shao-Rui, Pan 潘惠麟 Hui-Lin

Abstract excerpt

Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506), are commonly used immunosuppressants for preserving transplanted organs and tissues. However, these drugs can cause severe and persistent pain. GluA2-lacking, calcium-permeable AMPA receptors (CP-AMPARs) are implicated in various neurological disorders, including neuropathic pain. It is unclear whether and how constitutive calcineurin, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Calcineurin Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels

Share to Casein Kinase II

Share to Excitatory Postsynaptic Potentials

Share to Receptors, AMPA

Share to Spinal Cord

Share to Tacrolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 38886057
DOI: 10.1523/JNEUROSCI.0392-24.2024
PMCID: PMC11255431

Genes

CP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons.PMID 38886057Read ↗

α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly.Semantic proximity Read ↗

Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors.Semantic proximity Read ↗

AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors.Semantic proximity Read ↗

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit.Semantic proximity Read ↗

Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II.Semantic proximity Read ↗

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin.Semantic proximity Read ↗

Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.Semantic proximity Read ↗

Alternative splicing of the Ca2+ channel beta4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking.Semantic proximity Read ↗

Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.Semantic proximity Read ↗

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunitSemantic proximity Read ↗

Activity Dependent Inhibition of AMPA Receptors by Zn2.Semantic proximity Read ↗

α2δ-2 protein controls structure and function at the cerebellar climbing fiber synapseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.