Article
Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.
Nature neuroscience - 9 Oct 2011
Zonouzi Marzieh, Renzi Massimiliano, Farrant Mark, Cull-Candy Stuart G
Abstract excerpt
Oligodendrocyte precursor cells (OPCs), a major glial cell type that gives rise to myelinating oligodendrocytes in the CNS, express calcium-permeable AMPA receptors (CP-AMPARs). Although CP-AMPARs are important for OPC proliferation and neuron-glia signaling, they render OPCs susceptible to ischemic damage in early development. We identified factors controlling the dynamic regulation of AMPAR subtypes in OPCs...
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