Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase.

Nucleic acids research - 22 Jul 2024

Roy Priti, Walter Zachary, Berish Lauren, Ramage Holly, McCullagh Martin

Abstract excerpt

The Orthoflavivirus NS3 helicase (NS3h) is crucial in virus replication, representing a potential drug target for pathogenesis. NS3h utilizes nucleotide triphosphate (ATP) for hydrolysis energy to translocate on single-stranded nucleic acids, which is an important step in the unwinding of double-stranded nucleic acids. Intermediate states along the ATP hydrolysis cycle and conformational changes between these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to DEAD-box RNA Helicases
Share to Hydrolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleotides

Share to RNA Helicases

Share to Serine Endopeptidases

Share to Viral Nonstructural Proteins

Share to West Nile virus

Source

Open in PubMed Open full text

Identifiers

PMID: 38884215
DOI: 10.1093/nar/gkae500
PMCID: PMC11260461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase.PMID 38884215Read ↗

Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleftSemantic proximity Read ↗

Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase.Semantic proximity Read ↗

Integrative Structure of Norovirus NS3 Suggests a Role in RNA TransportSemantic proximity Read ↗

Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites.Semantic proximity Read ↗

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in MosquitoesSemantic proximity Read ↗

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.Semantic proximity Read ↗

Conserved motifs in the flavivirus NS3 RNA helicase enzymeSemantic proximity Read ↗

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.Semantic proximity Read ↗

Alteration of ssRNA Torsion and Water Influx into ssRNA Pocket in K309A and S247A Mutations.Semantic proximity Read ↗

A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicaseSemantic proximity Read ↗

Crystal structure of the Lassa virus nucleoprotein–RNA complex reveals a gating mechanism for RNA bindingSemantic proximity Read ↗

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.