Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alteration of ssRNA Torsion and Water Influx into ssRNA Pocket in K309A and S247A Mutations.

Current computer-aided drug design - 1 Jan 2021

Olaposi Omotuyi I

Abstract excerpt

BACKGROUND: Lassa Virus (LV) infection is an endemic disease from West Africa posing threat to the entire world. A thorough understanding of the mechanistic workings of the genome products of LV may be a key to develop drug candidates for the treatment of LV infection. METHODS: Molecular dynamic simulation has been used to provide insight into the mechanistic basis for total loss of ssRNA interaction in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome, Viral
Share to Hydrogen Bonding
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Nucleoproteins

Share to RNA, Viral

Source

Identifiers

PMID: 31648648
DOI: 10.2174/1573409915666191018124340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alteration of ssRNA Torsion and Water Influx into ssRNA Pocket in K309A and S247A Mutations.PMID 31648648Read ↗

Insight into the binding modes of Lassa nucleoprotein complexed with ssRNA by molecular dynamic simulations and free energy calculations.Semantic proximity Read ↗

Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase.Semantic proximity Read ↗

Crystal structure of the Lassa virus nucleoprotein–RNA complex reveals a gating mechanism for RNA bindingSemantic proximity Read ↗

Computational insights into the conformational transition of STING: mechanistic, energetic considerations, and the influence of crucial mutationsSemantic proximity Read ↗

Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924.Semantic proximity Read ↗

Computational insights into the conformational transition of STING: Mechanistic, energetic considerations, and the influence of crucial mutations.Semantic proximity Read ↗

S288T mutation altering MmpL3 periplasmic domain channel and H-bond network: A novel dual drug resistance mechanismSemantic proximity Read ↗

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.Semantic proximity Read ↗

An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5.Semantic proximity Read ↗

Molecular Basis for Reduced Cleavage Activity and Drug Resistance in D30N HIV-1 proteaseSemantic proximity Read ↗

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.Semantic proximity Read ↗

Exploring the mechanism of a regulatory SNP of KLK3 by molecular dynamics simulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.