Article
Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase.
Nucleic acids research - 1 Sept 2010
Despins Simon, Issur Moheshwarnath, Bougie Isabelle, Bisaillon Martin
Abstract excerpt
The West Nile virus RNA helicase uses the energy derived from the hydrolysis of nucleotides to separate complementary strands of RNA. Although this enzyme has a preference for ATP, the bias towards this purine nucleotide cannot be explained on the basis of specific protein-ATP interactions. Moreover, the enzyme does not harbor the characteristic Q-motif found in other helicases that regulates binding to ATP. In...
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