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Article

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

Nucleic acids research - 15 Dec 2017

Swarbrick Crystall M D, Basavannacharya Chandrakala, Chan Kitti W K, Chan Shu-Ann, Singh Daljit, Wei Na, Phoo Wint Wint, Luo Dahai, Lescar Julien, Vasudevan Subhash G

Abstract excerpt

The protein-RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5' genomic RNA 5'-AGUUGUUAGUCU-3' reveals that D290 and R538 make specific interactions with G2 and G5 bases respectively. We show that single-stranded 12-mer RNA stimulates ATPase activity of NS3, however the...

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Identifiers

PMID: 29165589
DOI: 10.1093/nar/gkx1127
PMCID: PMC5728396

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Source receipt: pubmed, retrieved 7 Sept 2026.

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