Article

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes

2020-05-27

Abstract excerpt

<h4>ABSTRACT</h4> The unwinding of double-stranded RNA intermediates is critical for replication and packaging of flavivirus RNA genomes. This unwinding activity is achieved by the ATP-dependent nonstructural protein 3 (NS3) helicase. In previous studies, we investigated the mechanism of energy transduction between the ATP and RNA binding pockets using molecular dynamics simulations and enzymatic characterization...

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Literature Corpus work: b05fd2b9-6ab1-5104-b45e-11ecb12c8e10
DOI: 10.1101/2020.05.26.117580

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